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Big Cat News / How cheetahs stay fit and healthy
« Last post by Crosis on March 27, 2017, 08:41:55 PM »
Cheetahs have a stronger constitutive innate immunity than leopards

Summary: Cheetahs are categorized as vulnerable species, partly because they have been considered to be prone to diseases due to their supposed weak immune system. However, they are hardly ever sick in the wild. A research team from the German Leibniz Institute for Zoo and Wildlife Research (IZW) recently discovered that cheetahs have developed a very efficient innate "first line of defense" immunity to compensate potential deficiencies in other components of their immune system. The scientists have published their results in the open access journal Scientific Reports of the Nature Publishing Group.

Cheetahs have a relatively low genetic variability which means that, within a population, the individuals have a similar genetic makeup. This is also true for the major histocompatibility complex (MHC), a genome region that regulates the so-called "adaptive" immune system and is typically highly variable in animal species. The adaptive immune system provides a rapid and specific defense against pathogens, if they have been encountered previously. A low MHC variability should therefore result in a weak adaptive immune system and thus a high vulnerability to diseases. This is often the case in species with low MHC variability, but there are some exceptions, the cheetah indeed being one of them. "During our long-term study that begun in 2002, we investigated more than 300 free-ranging cheetahs that live on farmland in Namibia. We did not encounter any cheetah with symptoms of acute infections, nor did we detect lesions in the examined dead animals," explains Bettina Wachter, head of the cheetah research project.

How can cheetahs cope so well with pathogens despite their supposedly weak adaptive immunity? The immune system is divided into three components:(1) the constitutive innate immune system, which provides a rapid first line of defense against intruders, (2) the induced innate immune system such as the local and systemic inflammatory response, which enhances recovery and decreases pathogen growth, and (3) the adaptive immune system.

"We decided to investigate all three components simultaneously, an approach that is rarely done although it is very promising. For every animal, a well-functioning immune system is associated with certain energetic costs. However, this does not imply that all immune components are equally strongly developed. If a species is not vulnerable to diseases, a good immune response must have evolved by strengthening other parts of the immune system," says Gábor Czirják, wildlife immunologist at the Leibniz-IZW.

To compare the results with another species, the scientists included leopards in the study. "Leopards live in the same habitat as cheetahs in Namibia, but they have a high variability in their MHC. Thus, leopards should have a strong adaptive immune system and might not invest that much energy in the other parts of the immune system," explains Wachter.

"We first needed to adapt six immunological tests from the toolbox of the wildlife immunology for the cheetah and leopard," explains Sonja Heinrich, first author of the study. "We conducted these tests at the laboratory of the Leibniz IZW, thus needed to transport the samples we collected in Namibia all the way to Germany, keeping the cooling chain uninterrupted from the captured animal in the field to the Leibniz IZW." The immunological tests confirmed that leopards have a stronger adaptive immune system than cheetahs, consistent with the differences in the MHC variability of both species. As expected, cheetahs had a stronger innate "first line of defense" immune system than leopards, thereby probably compensating their weak adaptive immune system.

The induced innate immune system reacts to pathogen intruders as well as to temporary stress. Therefore, the scientists also determined the concentration of the hormone cortisol, which activates catabolic processes and is increasingly released during stress. Although both species were exposed to the same capture and handling procedures leopards had significantly higher cortisol concentration in their blood than cheetahs, indicating that leopards reacted stronger to the examination methods. Thus, short-term stress might have stimulated the induced innate immune system, making it difficult to assess whether this immune part also helps to compensate the weak adaptive immune system of cheetahs, if the stress effect is not considered.

This is the first study in mammals demonstrating that different species spend varying efforts in the development of the different immune components. Cheetahs have apparently developed a way to successfully fight against pathogens despite their low genetic variability in their MHC. However, the future of this vulnerable species is highly uncertain because most of their habitat occurs in unprotected areas and they frequently come into conflicts with humans. Only if these conflicts can be mitigated, the cheetahs have a good chance to persist in the wild in the future.

Source: Forschungsverbund Berlin e.V. (FVB). (2017, March 23). How cheetahs stay fit and healthy. ScienceDaily. Retrieved March 27, 2017 from
General Animal Discussion / Re: My future Maine Coons
« Last post by Lionheart on March 14, 2017, 04:35:59 AM »
Beautiful goldie kitties, Tambako! I like your photos, and hope the cats and you have many many happy times together.
General Animal Discussion / Re: One eyed Snowmeow
« Last post by Lionheart on March 14, 2017, 04:34:35 AM »
Ugas, a lion who starred in the 1966 movie "Born Free", had to have an eye removed while George adamson was rewilding him in Africa. According to George, Ugas wasn't troubled by the loss, and seemed to gain extra popularity with the lionesses. Lionesses like an older male with scars from fights they have won.
Big Cat News / Re: Where Have Zimbabwe’s Cheetahs Gone?
« Last post by Crosis on March 07, 2017, 11:45:30 PM »
Well, I doubt nationalgeographic dares to blame politics.
General Animal Discussion / Re: My future Maine Coons
« Last post by Tambako on March 05, 2017, 04:43:37 PM »
And also of Pablo!
General Animal Discussion / Re: My future Maine Coons
« Last post by Tambako on March 05, 2017, 04:42:18 PM »
Some more pics!
General Animal Discussion / Re: My future Maine Coons
« Last post by Wotan on March 04, 2017, 03:32:23 PM »
4 more pictures for now

The last one reminds me of the meme on

"Yay! It's Caturday!"
General Animal Discussion / Re: One eyed Snowmeow
« Last post by Furlup on March 04, 2017, 04:59:34 AM »
Poor Ramil. I wonder how he goes with depth perception.
I've never had a chance to see a snow leopard in person :(

He was moving around his enclosure like it wasn't bothering him, jumping up on the rocks and logs. One of his keepers told me that his other eye is 100% healthy.
General Animal Discussion / Re: One eyed Snowmeow
« Last post by aydun on March 04, 2017, 03:58:16 AM »
Poor Ramil. I wonder how he goes with depth perception.
I've never had a chance to see a snow leopard in person :(
General Animal Discussion / Re: My future Maine Coons
« Last post by aydun on March 04, 2017, 03:53:25 AM »
What adorable kitties! And quite regal looking too.
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